FAS Inhibitors and Methods Associated Therewith
AssigneeWake Forest University
InventorsAaron M. Mohs, Steve J. Kreidel, Tanner K. Hill
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Abstract
The present invention relates to compounds, compositions and methods comprising nanoparticles (NP) that are based on hyaluronic acid (HLA) that have been modified with hydrophobic moieties that can entrap FASN inhibitor compounds. In one embodiment, the FASN inhibitor compounds include Orlistat. In one embodiment, the hydrophobic moieties comprise 5-βCA, Pba, or ODA, or combinations thereof. In a variation, the present invention relates to a composition comprising NPs based upon HLA, Orlistat, one or more of the hydrophobic moieties comprising 5-βCA, Pba, or ODA, and one or more of members selected from the group consisting of PEG and a dilute solution containing SDS.
Claims20
A pharmaceutical composition for treating cancer comprising nanoparticles that are based on hyaluronic acid that have been modified with one or more hydrophobic moieties that entrap FASN inhibitor compounds.
A method of treating cancer comprising administering to a subject in need thereof a pharmaceutically effective amount of a composition comprising hyaluronic acid containing nanoparticles modified with one or more hydrophobic moieties, and one or more FASN inhibitor compounds.
Dependencies are inferred from the claim text.