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US 2017/0360788 A1Published application
Small molecule inhibitors of egfr and pi3k
AssigneeThe Regents of the University of Michigan
InventorsChristopher Emil Whitehead, Judith S. Leopold
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Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.
Claims22
A compound described by Formula I:
- or Formula II
- including pharmaceutically acceptable salts, solvates, and/or prodrugs thereof;
- wherein R1 and R2 independently include any chemical moiety that permits the resulting compound to inhibit an EGFR protein and inhibit a PI3K protein.
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Dependencies are inferred from the claim text.