Protein Kinase C Inhibitors and Uses Thereof

A compound of formula (IVc)

• wherein
• R1, R2, R3, R4, R5, and R6 are independently selected from hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxyl, carboxyl, carboxylalkyl, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-substituted alkyl, —SO-aryl, —SO-heteroaryl, —SO2-alkyl, —SO2-substituted alkyl, —SO2-aryl and —SO2-heteroaryl;
• or R1 and R2 together form an oxo group;
• or R3 and R4 together form an oxo group;
• or R5 and R6 together form an oxo group;
• R7, R8, R9, and R10 are independently selected from hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxyl, carboxyl, carboxylalkyl, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-substituted alkyl, —SO-aryl, —SO-heteroaryl, —SO2-alkyl, —SO2-substituted alkyl, —SO2-aryl and —SO2-heteroaryl;
• or R7 and R8 together form an oxo group;
• or R9 and R10 together form an oxo group;
• R11 is selected from alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halogen, acyl, aminoacyl, nitro, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl;
• R20 is selected from hydrogen, alkyl, and substituted alkyl;
• Y1 and Y2 are independently selected from hydrogen and alkyl;
• and
• R12 is selected from hydrogen and halogen;
• R13 and R16 are hydrogen;
• R14 is —O-Alk-OR25, where Alk is an optionally substituted alkylene group and R25 is selected from hydrogen and an optionally substituted alkyl group;
• R15 is a substituted heterocyclyl;
• or a salt or stereoisomer thereof.