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AssigneeAbbVie Inc.
InventorsChristine Collins, Emily O. Dumas, Bo Fu, Abhishek Gulati, Yiran Bonnie Hu, Jens Kort, Matthew Kosloski, Preethi Krishnan, Yang Lei, Chih-Wei Lin, Ran Liu, Federico Mensa, Iok Chan Ng, Tami Pilot-Matias, David Pugatch, Susan Rhee, Nancy S. Shulman, Roger Trinh, Rolado M. Viani, Stanley Wang, Zhenzhen Zhang
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The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 16 weeks, alternatively no more than 12 weeks, or alternatively no more than 8 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 16, 12, or 8 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.
A method of treating or preventing a hepatitis C virus (HCV) genotype 1-6 infection in a transplant recipient receiving a solid organ from an HCV-infected donor, comprising administering two direct acting antiviral agents (DAAs) to the recipient once daily for a duration of no more than 16 weeks, wherein said method does not include administration of either interferon or ribavirin to said recipient, and wherein said two DAAs are (1) Compound 1 or a pharmaceutically acceptable salt thereof and (2) Compound 2 or a pharmaceutically acceptable salt thereof.
A method of treating a hepatitis C virus (HCV) genotype 1-6 infection in a transplant recipient, comprising administering two direct acting antiviral agents (DAAs) to the recipient once daily for a duration of no more than 16 weeks, wherein said method does not include administration of either interferon or ribavirin to said recipient, and wherein said two DAAs are (1) Compound 1 or a pharmaceutically acceptable salt thereof and (2) Compound 2 or a pharmaceutically acceptable salt thereof.
A method of treating a hepatitis C virus (HCV) genotype 1-6 infection in a treatment-experienced patient, comprising administering two direct acting antiviral agents (DAAs) to the patient once daily for a duration of no more than 16 weeks, wherein said method does not include administration of either interferon or ribavirin to said patient, and wherein said two DAAs are (1) Compound 1 or a pharmaceutically acceptable salt thereof and (2) Compound 2 or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.