Glutamate agents in the treatment of mental disorders
AssigneeYale University
InventorsVladimir Coric, John H. Krystal, Gerard Sanacora
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Abstract
Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.
Claims39
1-34. (canceled)
A method of treating a mental disorder in an individual in need thereof comprising administering to said individual an effective amount of riluzole in pharmaceutical dosage form in combination with at least one pharmaceutically acceptable carrier for administration via oral, buccal, vaginal, rectal or topical route of administration.
A pharmaceutical composition for use in treating a mental disorder in a human patient comprising an effective amount of riluzole in pharmaceutical dosage form in combination with at least one pharmaceutically acceptable carrier for administration via oral, buccal, vaginal, rectal or topical route of administration.
Dependencies are inferred from the claim text.