Compositions and methods of modulating s-nitrosylation
AssigneeCase Western Reserve University
InventorJonathan Stamler
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Abstract
A method of treating disorders associated with NO/SNO deficiency or benefiting from increased SNO in a subject in need thereof includes administering to the subject an ADH inhibitor, AKR inhibitor, SNO-CoAR inhibitor, and/or SNO-CoA at an amount(s) effective to promote S-nitrosylation of proteins in the subject.
Claims16
A method of treating disorders associated with NO/SNO deficiency or benefiting from increased SNO in a subject in need thereof, the method comprising:
- administering to the subject an ADH inhibitor, AKR inhibitor, and/or SNO-CoAR inhibitor at an amount(s) effective to promote S-nitrosylation of proteins in the subject, wherein the ADH inhibitor and/or SNO-CoAR inhibitor is not ADH3.
A method of treating disorders associated with NO/SNO deficiency or benefiting from increased SNO in a subject in need thereof, the method comprising:
- administering to the subject a yeast ADH6 inhibitor and/or mammalian AKRA1A inhibitor at an amount(s) effective to promote S-nitrosylation of proteins in the microbe or subject or sufficient to inhibit enzyme activity.
A method of promoting S-nitrosylation of proteins in a subject in need thereof, the method comprising:
- administering to the subject an ADH inhibitor, AKR inhibitor, and/or SNO-CoAR inhibitor at an amount(s) effective to promote S-nitrosylation of proteins in the subject, wherein the ADH inhibitor and/or SNO-CoAR inhibitor is not ADH3.
16-26. (canceled)
Dependencies are inferred from the claim text.