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US 2017/0360753 A1Published application
Organic compounds
AssigneeIntra-Cellular Therapies, Inc.
InventorsPeng LI, Hailin ZHENG, Gretchen SNYDER, Lawrence P. WENNOGLE, Joseph HENDRICK
Life of this patent
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Abstract
The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.
Claims11
A Compound of Formula I
- wherein
- (i) R1 is C1-4alkyl
- (ii) R2 is selected from the group consisting of:
- H,
- —OH,
- halo,
- C1-4alkyl,
- C1-4alkoxy,
- —N(Rf)(Rg),
- —C(O)N(Rh)(Ri),
- —C(O)ORj,
- —CN,
- C1-4alkylthio,
- heteroaryl,
- heteroC3-7cycloalkyl or pyrrolidinyl, and
- aryloxy wherein said aryl is optionally substituted with one or more halo;
- (iii) R3 is H or C1-4alkyl;
- (iv) Ra, Rb, Rc, Rd and Re are independently H, halo, —O—C1-6alkyl;
- (v) Rf and Rg are independently H, C1-4alkyl or heteroaryl;
- (vi) Rh and Ri are independently H or C1-4alkyl;
- (vii) Rj is H or C1-4alkyl;
- in free or salt form.
19 more elements
(canceled)
Dependencies are inferred from the claim text.