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US 2017/0360752 A1Published application
Antiviral agents directed against respiratory syncytial virus
AssigneesCentre National de la Recherche Scientifique (CNRS), Institut National De La Rechercheagronomique, Institut Pasteur, Universite Paris-Sud
InventorsChristina Sizun, Stéphane Duquerroy, Jean-François Eleouet, Felix Rey, Anny Slama Schwok, Didier Desmaele, Patrick Couvreur, Bogdan Tarus
Life of this patent
Estimating the term…
Abstract
The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus.
Claims17
An agent for use for treating an infection by respiratory syncytial virus (RSV), wherein said agent is represented in formula (I):
- wherein:
- R1 and R2 are identical or different and are independently chosen among hydrogen, hydroxyl, halogen, haloalkyl, alkyl, aryl, arylalkyl, nitro, cyano, amino, alkoxy, alkoxyalkyl, heteroaryl, cycloalkyl and heterocyclyl;
- and
- R3 and R4 are identical or different and are independently chosen among carboxylate, ester, substituted or non-substituted alkyloxycarbonyl, halogen, haloalkyl, alkyl, aryl, arylalkyl, nitro, cyano, amino, alkoxy, alkoxyalkyl, heteroaryl, cycloalkyl, heterocyclyl, boronate, phosphate, phosphonate, sulfinyl, sulfonyl, sulfonate, and sulfonamino, sulfonamido.
1 more element
A compound of formula (II):
- wherein
- R1 and R2 are independently halogens;
- and
- R5 and R6 are identical or different and are independently chosen among ester, substituted or non-substituted alkyloxycarbonyl, halogen, haloalkyl, alkyl, aryl, arylalkyl, nitro, cyano, amino, alkoxy, alkoxyalkyl heteroaryl, cycloalkyl, heterocyclyl, boronate, phosphate, phosphonate, sulfinyl, sulfonyl, sulfonate, sulfonamino, and sulfonamido,
- R5 and R6 do not represent a carboxylate group.
2 more elements
Dependencies are inferred from the claim text.