Method of preventing or treating a pulmonary disease or condition
AssigneeThe Board of Trustees of the University of Illinois
InventorsAnanatha Harijith, Viswanathan Natarajan, Roberto F. Machado, Jeffrey Jacobson
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition for aerosol administration and method of preventing or treating a pulmonary disease or condition in a subject with a SphK1 inhibitor are provided.
Claims10
A method of preventing or treating a pulmonary disease or condition in a subject comprising administering to a subject in need of treatment an effective amount of a SphK1 inhibitor to prevent or treat the subject's pulmonary disease or condition, wherein the SphK1 inhibitor
- (a) exhibits at least a 20-fold greater selectivity for SphK1 than SphK2;
- and
- (b) is cell permeable, has an IC50 value of less than 10 μM, or has a Ki of less than 10 μM, or a combination thereof.
A method of treating oxygen-induced lung injury in a subject comprising administering to a subject in need of treatment an effective amount of [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy] methyl]phenyl]methyl]pyrrolidin-2-yl]methanol (PF-543), or an analog, derivative or pharmaceutically acceptable salt thereof, to treat the subject's oxygen-induced lung injury.
A pharmaceutical composition for aerosol administration comprising one or more propellants and [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy] methyl]phenyl]methyl]pyrrolidin-2-yl]methanol (PF-543) or an analog, derivative or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.