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US 2017/0360748 A1Published application
Selective hdac6 inhibitors and uses thereof
AssigneeUniversiteit Gent
InventorsRob De Vreese, Matthias D'Hooghe
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Abstract
The present invention relates to selective Histone deacetylase 6 (HDAC6) inhibitors and compositions containing the same. Methods of treating diseases and conditions wherein inhibition of HDAC6 provides a benefit, like a cell proliferative disease, an autoimmune or inflammatory disorder, a neurodegenerative disease, or a combination thereof, also are disclosed.
Claims20
A compound of formula I, or a stereoisomer, tautomer, racemic, salt, hydrate or solvate thereof
- wherein
- A is selected from NR, O and S;
- R is selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6haloalkyl, cycloalkyl, benzyl, and aryl;
- R1 is selected from the group consisting of hydrogen, halogen, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6haloalkyl, amino, nitro, hydroxyl, cyano, cycloalkyl, aryl, heterocyclyl, heteroaryl, OR′, SR′, NR′R″, and P(O)(OR′)(OR″);
- R′ and R″ are independently selected from the group consisting of hydrogen, C1-6alkyl, and aryl;
- R2 is selected from the group consisting of hydrogen, halogen, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6haloalkyl, amino, nitro, cycloalkyl, aryl, heterocyclyl, and heteroaryl;
- R3 is selected from hydrogen, C1-6alkyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl;
- wherein said C1-6alkyl is optionally substituted with halogen, amino, nitro, cycloalkyl, aryl, heterocyclyl, or heteroaryl;
- and
- R4 is selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6haloalkyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl.
7 more elements
(canceled)
-16. (canceled)
Dependencies are inferred from the claim text.