Topical dapsone and dapsone/adapalene compositions and methods for use thereof
AssigneeAllergan, Inc.
InventorsKevin S. Warner, Ajay P. Parashar, Vijaya Swaminathan, Varsha Bhatt
Life of this patent
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Abstract
Dapsone and dapsone/adapalene compositions can be useful for treating a variety of dermatological conditions. The compositions of this disclosure include dapsone and/or adapalene in a polymeric viscosity builder. Subject compositions can be adjusted to optimize the dermal delivery profile of dapsone to effectively treat dermatological conditions and improve the efficiency of pharmaceutical products applied to the skin. Use of the polymeric viscosity builder provides compositions with increased concentrations of diethylene glycol monoethyl ether relative to compositions without the polymeric viscosity builder.
Claims14
A topical pharmaceutical composition comprising:
- about 5% w/w to about 10% w/w dapsone;
- about 0.1% w/w to about 0.3% adapalene;
- about 30% w/w to about 40% w/w diethylene glycol monoethyl ether;
- about 2% w/w to about 6% w/w of a polymeric viscosity builder comprising acrylamide/sodium acryloyldimethyl taurate copolymer;
- and
- water.
A method of treatment of acne vulgaris, the method comprising administration of a topical pharmaceutical composition to a patient in need thereof, the topical pharmaceutical composition comprising:
- about 5% w/w to about 10% w/w dapsone;
- about 0.1% w/w to about 0.3% adapalene;
- about 30% w/w to about 40% w/w diethylene glycol monoethyl ether;
- about 2% w/w to about 6% w/w of a polymeric viscosity builder comprising acrylamide/sodium acryloyldimethyl taurate copolymer;
- and
- water.
Dependencies are inferred from the claim text.