Methods of preventing neurodegeneration of association cortex in a mammal
AssigneeYale University
InventorAmy F. T. ARNSTEN
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Abstract
The present invention provides methods of preventing and/or reducing risk of neurodegeneration of association cortex, and/or inhibiting or reversing formation of phosphorylated tau or COXIV in the prefrontal cortex of a mammal in need thereof. In certain embodiments, the method comprises administering to the mammal a therapeutically effective amount of an α2A-adrenergic receptor agonist.
Claims20
A method of (i) preventing or reducing risk of cortical degeneration in a mammal in need thereof or (ii) inhibiting or reversing formation of phosphorylated tau or phosphorylated cytochrome oxidase subunit IV (COXIV) in the prefrontal cortex of a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of at least one α2A-adrenergic receptor agonist.
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Dependencies are inferred from the claim text.