Carrier-free nanoparticles
AssigneePurdue Research Foundation
InventorsYoon Yeo, Joonyoung Park, Bo Sun
Life of this patent
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Abstract
A carrier free nanoparticle formulation with good circulation stability is made for anticancer drug delivery. Nanocrystals crystalized in the medium containing Pluronic F-127 then coated with albumin (Cim-F-Alb) had the smallest size and the most native albumin, and showed most favorable cell interaction profiles and better stability than commercial albumin based Abraxane formulation, while maintaining comparable cytotoxicity to those of Abraxane and solvent-dissolved paclitaxel (PTX).
Claims16
A carrier-free nanoparticle comprising a drug crystalline, formed in a surfactant-containing medium, coated with a native protein or polysaccharide, wherein the protein/polysaccharide to the drug crystalline ratio ranges from about 1:10 to about 5:10 and the nanoparticle ranges in size between about 100 nm to about 300 nm.
A method for making carrier-free nanoparticles, comprising:
- crystallizing a drug in a surfactant-containing medium to form a crystalline incipient film;
- hydrating the crystalline incipient film with bath sonication to form hydrated suspension;
- and
- stabilizing the hydrated suspension with a surface modifier, wherein said surface modifier is adsorbed on the crystalline surface via the surfactant.
Dependencies are inferred from the claim text.