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US 2017/0360689 A1Published application
Delivery of hydrophobic bioactive agents
OwnerJohn E. Kuleszainventor
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Abstract
A composition for delivery of a hydrophobic bioactive agent is provided that provides for a partially solubilized storage solution that upon exposure to the air results in a fully solubilized bioactive agent in a molecular form for optimal delivery to the skin of a subject. The composition is used for the therapeutic treatment or diagnosis of numerous skin conditions such as inflammation, and epidermal or musculoskeletal pain.
Claims17
A composition for topical delivery of a bioactive agent to a subject comprising:
- a bioactive agent selected from the group consisting of a corticosteroid and a hydroxy acid;
- a non-volatile solvent into which said bioactive agent is soluble, said solvent selected from the group consisting of dimethylisosorbide, ethoxydiglycol, and a combination thereof;
- a silicone in which said bioactive agent is insoluble, said silicone volatile at standard temperature and pressure;
- and
- a dimethicone crosspolymer thickener;
- said bioactive agent, said solvent, and said silicone present at concentrations to place said bioactive agent in a saturated or super-saturated state in said composition such that a portion of said bioactive agent is in a crystalline state.
3 more elements
Dependencies are inferred from the claim text.