Compostions and methods for tissue repair
AssigneeWashington University
InventorsStephen Linderman, Guy Genin, Stavros Thomopoulos, Kollbe Ahn, Victor Mark Birman
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Abstract
Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including CTGF/CCN2, or cells.
Claims19
A composition comprising an adhesive film or adhesive layer for use in a subject with a tissue defect.
A method of repairing a tissue defect at a tissue defect site comprising:
- (i) providing a film or a layer;
- (ii) contacting the film or the layer with an adhesive agent;
- (iii) delivering the film or the layer to a tissue defect;
- and
- (iv) applying an adhesive to the film, the layer, or a tissue.
A method of surgical repair of a tissue defect, the tissue defect comprising a first tissue and a second tissue, comprising:
- (i) connecting a first tissue and second tissue in a subject;
- (ii) implanting a film or a layer into a subject in need thereof;
- and
- (iii) connecting a first tissue to a second tissue with an anchored suture, wherein
- the film or the layer is implanted between the first tissue;
- and
- the film or the layer comprises an adhesive.
Dependencies are inferred from the claim text.