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US 2017/0360037 A1Published application
3′-substituted-abscisic acid derivatives
AssigneeValent BioSciences Corporation
InventorsGary T. Wang, Daniel F. Heiman, Gregory D. Venburg, Eiki Nagano, Marci Surpin, Joseph H. Lustig
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Abstract
The invention relates to a novel class of (S)-3′-substituted-abscisic acid derivatives and (±)-3′-substituted-abscisic acid derivatives, and methods of synthesizing the derivatives.
Claims30
An enantiomerically pure compound of Formula I:
- wherein:
- n is 0 or 1;
- when n is 0, R1 is substituted or unsubstituted C2-C20 alkyl, cycloalkyl or heterocycloalkyl;
- when n is 1, R1 is cyano (—CN), carboxylate (—CO2H), alkoxycarbonyl (—CO2R′), unsubstituted, monosubstituted or disubstituted carbamoyl (—CONR′R″), substituted or unsubstituted alkenyl, cycloalkenyl, alkynyl, aryl, or heteroaryl;
- R2 is hydrogen, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, or heteroaryl;
- and
- R′ and R″ are hydrogen, substituted or unsubstituted C1-C20 straight or branched chain alkyl, cycloalkyl or heterocycloalkyl;
- and salts thereof.
5 more elements
A compound of Formula II:
- wherein:
- n is 0 or 1;
- when n is 0, R is fluoromethyl, difluoromethyl, trifluoromethyl, substituted or unsubstituted C2-C20 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- when n is 1, R is alkenyl, cycloalkenyl, alkynyl, aryl or heteroaryl;
- and salts thereof.
2 more elements
Dependencies are inferred from the claim text.