Animal model for dry eye and methods of use of such animals
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsMing YUAN, Ying HU, Jingtai CAO, Carmelo ROMANO
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Abstract
Provided herein are methods for creating an animal model for the study of dry eye and methods of using such animal models to test candidate treatments for ocular conditions and determine the efficacy of such treatments.
Claims23
A method of inducing dry eye disease in a rodent animal, comprising administration of scopolamine and benzalkonium chloride to said rodent animal.
A method of testing the efficacy of a candidate agent for the treatment of dry eye, comprising providing a rodent animal, administering scopolamine and benzalkonium chloride to said rodent animal to induce dry eye in said rodent animal, administering said candidate agent to said rodent animal, and determining whether said candidate agent is effective in treating dry eye in said rodent animal.
Dependencies are inferred from the claim text.