Fusion proteins, recombinant bacteria, and exosporium fragments for animal health and aquaculture

2-30. (canceled)

A pharmaceutical composition comprising a pharmaceutically acceptable carrier and exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one protein or peptide that protects an animal from a pathogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member.

32-36. (canceled)

38-64. (canceled)

A method for protecting an animal from a pathogen comprising administering to the animal, to the environment of the animal, or to the pathogen:

• spores of a recombinant Bacillus cereus family member that expresses a fusion protein, the fusion protein comprising at least one protein or peptide that protects the animal from a pathogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member, wherein the protein or peptide that protects the animal from a pathogen does not comprise an antigen or an immunogen;
• exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one protein or peptide that protects the animal from a pathogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• or a combination thereof.

66-119. (canceled)

A composition comprising a carrier acceptable for use in aquaculture and exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one protein or peptide that protects an aquatic organism from a pathogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member.

121-123. (canceled)

125-161. (canceled)

An adhesive patch, wound dressing, or hoof bandage comprising a pharmaceutical composition, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier and:

• spores of a recombinant Bacillus cereus family member that expresses a fusion protein, the fusion protein comprising at least one protein or peptide that protects an animal from a pathogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one protein or peptide that protects an animal from a pathogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• or a combination thereof.

163-176. (canceled)

178-191. (canceled)

Feed or a feed additive comprising exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one protein or peptide that protects an animal from a pathogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member.

193-229. (canceled)

A nematicidal, insecticidal, or acaricidal composition comprising a carrier and exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising:

• a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• and
• at least one nematicidal protein or peptide, or at least one protein or peptide that has insecticidal or acaricidal activity against an insect or arachnid vector of an animal pathogen or larvae or instars of the insect or arachnid vector.

231-235. (canceled)

A method for protecting an animal from a pathogen by killing an insect or arachnid vector of the pathogen, wherein the method comprises contacting the insect or arachnid vector or larvae of the insect or arachnid vector with:

• spores of a recombinant Bacillus cereus family member that expresses a fusion protein, the fusion protein comprising at least one protein or peptide that has insecticidal or acaricidal activity against an insect or arachnid vector of an animal pathogen or larvae of the insect or arachnid vector and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one protein or peptide that has insecticidal or acaricidal activity against an insect or arachnid vector of an animal pathogen or larvae of the insect vector and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• or a combination thereof.

237-242. (canceled)

An insect fogger comprising a composition comprising a carrier and:

• spores of a recombinant Bacillus cereus family member that expresses a fusion protein, the fusion protein comprising at least one protein or peptide that has insecticidal or acaricidal activity against an insect or arachnid vector of an animal pathogen or larvae or instars of the insect or arachnid vector and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• exosporium fragments, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one protein or peptide that has insecticidal or acaricidal activity against an insect or arachnid vector of an animal pathogen or larvae or instars of the insect or arachnid vector and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;
• or a combination thereof.

244-261. (canceled)

A method for producing an immunogenic response in an aquatic animal comprising administering exosporium fragments to the aquatic animal, wherein the exosporium fragments are derived from spores of a recombinant Bacillus cereus family member and comprise a fusion protein, the fusion protein comprising at least one antigen or immunogen and a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of the recombinant Bacillus cereus family member;

• and wherein the aquatic animal is selected from fish, amphibians, crustaceans, mollusks, and combinations of any thereof.

266-267. (canceled)

269-281. (canceled)

284-306. (canceled)

308-325. (canceled)