Egfr inhibitor compounds

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein Formula (I) has the structure:

• R1 is selected from hydrogen, halogen, hydroxy, cyano, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 haloalkyl, an optionally substituted C1-4 alkoxy and an optionally substituted C1-4 haloalkoxy;
• R2 is an optionally substituted 6-15 membered heteroaryl or an optionally substituted 6-15 membered heterocyclyl, wherein the heteroaryl and the heterocyclyl independently contains 1-4 heteroatoms selected from N, O and S;
• R3 is selected from hydrogen, halogen, an optionally substituted C1-4 alkyl, an optionally substituted C3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl, wherein when substituted, R3 is substituted by one or more substituents selected from halogen, cyano, an unsubstituted C1-4 alkyl, an optionally substituted aryl, —C(O)R5A, —SO2R5B, —NHC(O)R5C and —(CR6AR6B)nNR7AR7B;
• X1 is O, S or NR4;
• R4 is selected from hydrogen, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 haloalkyl and an optionally substituted C3-8 cycloalkyl;
• R5A, R5B and R5C are independently selected from hydrogen, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 haloalkyl, an optionally substituted C3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl;
• R6A and R6B are independently selected from hydrogen, halogen, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 haloalkyl and an optionally substituted C3-8 cycloalkyl;
• R7A and R7B are independently selected from hydrogen, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 haloalkyl and an optionally substituted C3-8 cycloalkyl;
• A1 is N or CR8;
• R8 is selected from hydrogen, halogen, cyano, an optionally substituted C1-4 alkyl, an optionally substituted C1-4 haloalkyl and an optionally substituted C3-8 cycloalkyl;
• m is 0 or 1;
• and
• n is 0, 1, 2 or 3;
• and
• provided that R2 is substituted with bicyclo[1.1.1]pentyl or R3 is a substituted bicyclo[1.1.1]pentyl.