Tetrafunctional bacteriophage
AssigneeImperial Innovations Limited
InventorsAmin Hajitou, Teerapong Yata
Life of this patent
Estimating the term…
Abstract
The invention provides a recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage. The bacteriophage comprises a first nucleic acid sequence encoding a pill capsid minor coat protein that is configured to display a cell-targeting ligand for enabling delivery of the bacteriophage to a target cell, a second nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a foreign peptide thereon, and a transgene which encodes a protein which exerts a biological effect on the target cell.
Claims40
A recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage, the bacteriophage comprising a first nucleic acid sequence encoding a pIII capsid minor coat protein that is configured to display a cell-targeting ligand for enabling delivery of the bacteriophage to a target cell, a second nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a foreign peptide thereon, and a transgene which encodes a protein which exerts a biological effect on the target cell.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage, the bacteriophage comprising a nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display an endosome escape peptide (EEP) thereon, and a transgene which encodes a protein which exerts a biological effect on a target cell transduced by the bacteriophage.
A recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage, the bacteriophage comprising a nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a nuclear localization signal (NLS) peptide thereon, and a transgene which encodes a protein which exerts a biological effect on a target cell transduced by the bacteriophage.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.