Nanoparticles and their use in cancer therapy
AssigneeMidatech Limited
InventorsJon Golding, Phillip Williams, Meike Roskamp
Life of this patent
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Abstract
The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.
Claims21
-22. (canceled)
A method of treatment of a cancer in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a nanoparticle comprising a core comprising a metal;
- and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group.
(canceled)
An article of manufacture comprising:
- a nanoparticle comprising a core comprising a metal;
- and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group;
- a container for housing the nanoparticle;
- and
- an insert or label with administration and/or dosage instructions for the treatment of a cancer, optionally wherein the cancer is selected from the group consisting of:
- squamous cell carcinoma (SCC), cervical cancer, skin cancer, oral cancer, glioma, lung cancer, bladder cancer, ocular cancer, stomach cancer, and esophageal cancer.
Dependencies are inferred from the claim text.