Microorganism having improved ability to produce n-acetylglucosamine as a result of modulating glycolytic flux
AssigneeKorea University Research and Business Foundation
InventorsMin-Kyu Oh, Sang-Woo Lee
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Abstract
The present invention relates to a mutant microorganism in which a gene that encodes phosphofructokinase-2 is disrupted or deleted to reduce glycolytic flux to thereby improve the ability of the microorganism to produce N-acetylglucosamine, and to a method of producing N-acetylglucosamine using the mutant microorganism. The mutant microorganism according to the present invention has advantages in that it has high resistance to various chemical substances, grows rapidly, is easily cultured, and produces N-acetylglucosamine with high efficiency, indicating that it is useful for production of a large amount of N-acetylglucosamine.
Claims9
A mutant microorganism having an improved ability to produce N-acetylglucosamine in which a gene encoding phosphofructokinase-2 (PFK-2) is disrupted or deleted in a microorganism having glycolysis and N-acetylglucosamine biosynthesis pathways.
Dependencies are inferred from the claim text.