Cystathionine-gamma-lyase (cse) inhibitors
AssigneeSova Pharmaceuticals, Inc.
InventorsSergio G. DURÓN, Justin CHAPMAN, Simon G. SYDSERFF, Srinivas G. RAO, Gregory STEIN, Warren WADE
Life of this patent
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Abstract
Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.
Claims23
A compound of Formula (I) having the structure:
- wherein:
- A is a carboxylic acid isostere;
- R1 is substituted or unsubstituted C3-C6alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
A compound of Formula (II) having the structure:
- wherein:
- R1 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- A is selected from
- or
- a pharmaceutically acceptable salt, solvate, or prodrug thereof.
A compound of Formula (III) having the structure:
- wherein:
- R1 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- A is a carboxylic acid isostere selected from —SO3H, —SO2NHR4, —P(O)(OR4)2, —P(O)(R4)(OR4), —CON(R4)2, —CONHNHSO2R4, —CONHSO2R4, —C(R4)2B(OR5)2, and —CON(R4)C(R4)2B(OR5)2;
- wherein each R4 is independently H, OH, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl;
- and R5 is H or C1-C6alkyl;
- or
- a pharmaceutically acceptable salt, solvate, or prodrug thereof.
A compound of Formula (IV) having the structure:
- wherein:
- A is
- R1 is substituted or unsubstituted C2-C6alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
A compound of Formula (V) having the structure:
- wherein:
- A is
- R1 is H, substituted or unsubstituted C3-C6alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
Dependencies are inferred from the claim text.