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US 2017/0327460 A1Published application
Hydrodabcyl
AssigneeUniversitat Bayreuth
InventorsElisa BOMBARDA, Oxana KEMPF, Karl KEMPF, Rainer SCHOBERT, G. Matthias ULLMANN
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Abstract
A new azobenzene-based fluorescence quencher with excellent solubility in aqueous solution is described here. This compound represents an optimized alternative to dabcyl in a variety of biomolecular applications, like fluorogenic protease substrates or nucleic acids probes.
Claims11
A compound having formula (I)
Method of producing a compound having formula (I)
- wherein the method comprises the steps of
- a) producing 5-dimethylamino-resorcinol (5-(dimethylamino)benzene-1,3-diol)
- by reacting phloroglucinol (benzene-1,3,5-triol) with dimethylamine (HN(CH3)2) to obtain 5-dimethylamino-resorcinol;
- and
- b) azo-coupling 4-diazo-salicylic acid to 5-dimethylamino-resorcinol to obtain the compound having formula (I).
2 more elements
(canceled)
Dependencies are inferred from the claim text.