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US 2017/0327456 A1Published application
Process for making modulators of cystic fibrosis transmembrane conductance regulator
AssigneeVertex Pharmaceuticals Incorporated
InventorsJohn DEMATTEI, Adam R. LOOKER, Bobbianna NEUBERT-LANGILLE, Martin TRUDEAU, Stefanie ROEPER, Michael P. RYAN, Dahrika Milfred Yap GUERETTE, Brian R. KRUEGER, Peter D.J. GROOTENHUIS, Fredrick F. VAN GOOR, Martyn C. BOTFIELD, Gregor ZLOKARNIK
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Abstract
The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
Claims2
A compound having the formula:
A pharmaceutically acceptable salt of a compound having the formula:
Dependencies are inferred from the claim text.