Loading patent…
AssigneesPublic University Corporation Yokohama City University, Tosoh Corporation
InventorsNoriaki ARAKAWA, Hisashi HIRANO, Etsuko MIYAGI, Norihisa OHTAKE
Estimating the term…
The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.
A processed tissue factor pathway inhibitor 2 (TFPI2) polypeptide having the following properties (i) to (iii):
A reagent for detecting ovarian clear cell adenocarcinoma, comprising an antibody that binds to an antigenic determinant in the region from the 23th residue aspartic acid to the 131st residue histidine or to the 130th residue cysteine in the TFPI2 amino acid sequence of SEQ ID NO:1.
Dependencies are inferred from the claim text.