A Novel Auto-Active and Intracellular Mutant of MET
AssigneesStichting Katholieke Universiteit, Stichting Vu-Vumc
InventorsAnna Catharina Navis, Wilhelmus Petrus Johannes Leenders, Thomas Würdinger
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Abstract
The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.
Claims15
A method for determining the presence of an auto-active and intracellular mutant MET, comprising:
- a. analysis of genomic DNA to detect a chromosomal deletion in chromosome 7, resulting in loss of part of intron 6, exon 7, intron 7 and part of exon 8,
- b. analysis of mRNA or cDNA to detect substantial absence of exons 7 and 8, and/or
- c. analysis of MET protein to determine whether the MET protein is exclusively located intracellularly or whether at least part is on the cell surface.
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A biomarker for determining the presence of a MET mutant in a sample, wherein the MET mutant is an auto-active and intracellular mutant MET and wherein the biomarker preferably is an oligonucleotide, an antibody or a conjugate thereof or an array comprising a multiplicity of such biomarker.
Dependencies are inferred from the claim text.