Projected capacitive multi electrode eukaryotic cell array
AssigneeStemoniX Inc.
InventorRobert John Petcavich
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Abstract
The present subject matter discloses various exemplary projective capacitive micro structured electrode arrays for measuring the impedance and action potential of living cells in particular induced pluripotent stem cells that are subsequently differentiated into cardiomyocytes and neurons. In one exemplary system a projective capacitive electrode array with cardiomyocytes attached onto the electrodes is formed and electrical measurements of live cell responses when exposed to external stimulants, such as small molecule drugs or biologically active compounds is recorded.
Claims21
A projective capacitive electrode array for real time measurement of living cell electrophysiology.
A method of forming a micro structured electrode array for measurement of living cells, comprising:
- forming an array of patterned electrodes on a substrate having space/trace dimensions varying from 5 microns by 5 microns to 500 microns by 500 microns in any combination of aforementioned dimensions;
- attaching the substrate to a microwell plate;
- and
- providing a connection to the array of patterned electrodes for use by a microcontroller such that the electrical characteristics of the array electrodes can be measured and monitored.
Dependencies are inferred from the claim text.