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US 2017/0322180 A1Published application
Pressure driven microfluidic injection for chemical separations
AssigneeThe University of North Carolina at Chapel Hill
InventorsJohn Scott Mellors, Erin Anne Redman, John Michael Ramsey
Life of this patent
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Abstract
Methods that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer.
Claims29
(canceled)
A method, comprising:
- initiating injection of a fluid sample from a first reservoir into a first channel of a fluidic device by applying a first pressure to the fluid sample in the first reservoir, thereby causing at least a portion of the fluid sample to enter the first channel;
- and
- terminating injection of the fluid sample by applying a second pressure to a background fluid in a second reservoir, thereby causing background fluid to flow in a uniform direction within the first channel,
- wherein no electrical potential is applied across the fluid sample to inject the sample into the first channel.
1 more element
A sample analysis system, comprising:
- a fluidic chip comprising a first fluid reservoir, a second fluid reservoir, and a first channel in fluid communication with the first and second fluid reservoirs;
- a first gas source in fluid communication with the first fluid reservoir;
- a second gas source in fluid communication with the second fluid reservoir;
- and
- an electronic processor connected to the first and second gas sources,
- wherein during operation of the system, the electronic processor is configured to:
- initiate injection of a fluid sample from the first fluid reservoir into the first channel by applying a first gas pressure to the first fluid reservoir, thereby causing at least a portion of the fluid sample to enter the first channel;
- and
- terminate injection of the fluid sample by applying a second gas pressure to the second fluid reservoir, thereby causing background fluid to flow from the second fluid reservoir to flow in a uniform direction within the first channel;
- and
- wherein no electrical potential is applied across the fluid sample to inject the sample into the first channel.
8 more elements
Dependencies are inferred from the claim text.