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US 2017/0321185 A1Published application
Efficient production of oligosaccharides using metabolically engineered microorganisms
AssigneeCentre National de la Recherche Scientifique (CNRS)
InventorEric SAMAIN
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Abstract
The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moieties of the gangliosides GM3, GD3, and G.
Claims20
1-21. (canceled)
A microorganism comprising a heterologous gene encoding a bifunctional Campylobacter jejuni sialytransferase polypeptide that catalyzes the transfer of a sialyl moiety from an activated sialic acid molecule to lactose to form Neu5Acα-3Galβ-4Glc and a heterologous gene encoding a cytidine monophospho-(CMP)-sialic acid synthetase.
Dependencies are inferred from the claim text.