Automatic dishwashing detergent composition
AssigneeThe Procter & Gamble Company
InventorsMichelle JACKSON, Eva Maria PEREZ-PRAT VINUESA, David John TARBIT, Philip Frank SOUTER, Euan John MAGENNIS, David Edward WILDES, Jeffrey W. MUNOS, Neelam S. AMIN, David L. MARQUEZ, Victoria HUANG, Geetha VEERAMUTHU, Rei OTSUKA
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Abstract
A phosphate-free automatic dishwashing cleaning composition including an organic complexing agent and a new protease.
Claims20
A phosphate-free automatic dishwashing cleaning composition comprising an organic complexing agent and a protease wherein the protease is a variant of a parent protease having the amino acid sequence of SEQ ID NO:1 having at least 80% identity with the amino acid sequence of SEQ ID NO:1 and comprising one of the following combinations of two amino acid substitutions selected from the group consisting of:
- S3V+S78N;
- N18R+G20R;
- N18R+S24R;
- N18R+N43R;
- N18R+R45T;
- N18R+H249R;
- G20R+N43R;
- G20R+R45T;
- G20R+H249R;
- T22L+S24F;
- T22L+S78N;
- T22L+S166D;
- T22L+T213A;
- S24R/F+S78N;
- S24R+N43R;
- S24R+Y209W;
- S24F+S166D;
- S24R/F+T213A;
- S24R+H249R;
- S24R+M222Q;
- N43R+Y209W;
- N43R+H249R;
- N43R+R45T;
- R45T+H249R;
- S78G/N+Q206Y/F;
- S78N+S166D;
- S78N+Q206L;
- S78N+Y209W;
- S78N+T213A;
- S101A+S188D;
- S101A+P210I;
- S101A+A232V;
- S103A+S188D;
- S103A+P210I;
- S103A+A232V;
- V104I+S188D;
- V104I+P210I;
- V104I+A232V;
- S166D+T213A;
- S188D+P210I;
- S188D+A232V;
- S188D+Q245R;
- P210I+A232V;
- A232V+Q245R;
- Q206L+M222Q;
- Q206L+H249R;
- Q206Y+T213A;
- Q206Y+M222Q;
- M222Q+H249R;
- Y209W+M222Q;
- T213A+H249R;
- Y209W+H249R
- in combination with one or more substitutions at the following positions 76, 87, 118, 128, 129, 130 according to BPN′ numbering.
Dependencies are inferred from the claim text.