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US 2017/0321016 A1Published application
Linkers for protein interaction profiling and methods of making and using the same
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsWilliam OLD, Douglas A. CHAPNICK, Tristan D. MCCLURE-BEGLEY, Tao GONG, Brady WORRELL, Christopher C. EBMEIER, Christopher BOWMAN
Life of this patent
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Abstract
Crosslinking compounds for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins, peptides and nucleic acids.
Claims29
A crosslinking compound having the chemical structure:
- Z-An-Z
- wherein:
- n is an integer between 1 and 5;
- A is an atom or compound;
- and,
- each Z is a Michael acceptor, and
- A is optionally linked to at least one of an affinity handle (Q), and a molecular label (L).
4 more elements
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A cross-linking compound, having the chemical structure
- Z-Y-An-Y-Z
- wherein
- each Z is a Michael acceptor,
- A is an atom or compound;
- n is an integer between 1 and 5;
- and,
- each Y is independently an organic compound of C1-10 alkyl, optionally substituted with one or more heteroatoms selected from O, N, S, or P.
4 more elements
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36-59. (canceled)
Dependencies are inferred from the claim text.