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US 2017/0320962 A1Published application
Monoclonal antibodies against c-met
AssigneeGenmab A/S
InventorsJoost J. NEIJSSEN, Bart DE GOEIJ, Edward Norbert VAN DEN BRINK, Aran Frank LABRIJN, Rene HOET, Janine SCHUURMAN, Paul PARREN, Jan VAN DE WINKEL
Life of this patent
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Abstract
Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
Claims6
1-29. (canceled)
A nucleotide sequence encoding one or more of the amino acid sequences selected from the group consisting of SEQ ID NO:
- 1, 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 57, 61, 65, 69, 73, 77, 81, 85, 89, 93, 97, 101, 105, 109, 113, 117, 121, 125, 129, 133, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177 and 178.
A method for detecting the presence of c-Met in a sample, comprising:
- contacting the sample with a human monoclonal antibody which binds human c-Met under conditions that allow for formation of a complex between the antibody and c-Met;
- and
- analyzing whether a complex has been formed.
Dependencies are inferred from the claim text.