Novel anti-mfi2 antibodies and methods of use
AssigneeAbbvie Stemcentrx LLC
InventorsSAMUEL WILLIAMS, LAURA SAUNDERS, HOLGER KARSUNKY, MANDY BOONTANRART
Life of this patent
Estimating the term…
Abstract
Provided are novel anti-MFI2 antibodies and antibody drug conjugates, and methods of using such anti-MFI2 anti-bodies and antibody drug conjugates to treat cancer.
Claims32
An antibody that competes for binding with an isolated antibody that binds to a cell expressing human MFI2 having SEQ ID NO:
- 3, wherein the isolated antibody comprises:
- (1) a light chain variable region (VL) of SEQ ID NO:
- 21 and a heavy chain variable region (VH) of SEQ ID NO:
- 23;
- or
- (2) a VL of SEQ ID NO:
- 25 and a VH of SEQ ID NO:
- 27;
- or
- (3) a VL of SEQ ID NO:
- 29 and a VH of SEQ ID NO:
- 31;
- or
- (4) a VL of SEQ ID NO:
- 33 and a VH of SEQ ID NO:
- 35;
- or
- (5) a VL of SEQ ID NO:
- 37 and a VH of SEQ ID NO:
- 39;
- or
- (6) a VL of SEQ ID NO:
- 41 and a VH of SEQ ID NO:
- 43;
- or
- (7) a VL of SEQ ID NO:
- 45 and a VH of SEQ ID NO:
- 47;
- or
- (8) a VL of SEQ ID NO:
- 49 and a VH of SEQ ID NO:
- 51;
- or
- (9) a VL of SEQ ID NO:
- 53 and a VH of SEQ ID NO:
- 55;
- or
- (10) a VL of SEQ ID NO:
- 57 and a VH of SEQ ID NO:
- 59;
- or
- (11) a VL of SEQ ID NO:
- 61 and a VH of SEQ ID NO:
- 63;
- or
- (12) a VL of SEQ ID NO:
- 65 and a VH of SEQ ID NO:
- 67;
- or
- (13) a VL of SEQ ID NO:
- 69 and a VH of SEQ ID NO:
- 71;
- or
- (14) a VL of SEQ ID NO:
- 73 and a VH of SEQ ID NO:
- 75;
- or
- (15) a VL of SEQ ID NO:
- 77 and a VH of SEQ ID NO:
- 79;
- or
- (16) a VL of SEQ ID NO:
- 81 and a VH of SEQ ID NO:
- 83;
- or
- (17) a VL of SEQ ID NO:
- 85 and a VH of SEQ ID NO:
- 87;
- or
- (18) a VL of SEQ ID NO:
- 89 and a VH of SEQ ID NO:
- 91.
A humanized antibody that binds to MFI2 comprising a light chain variable region and a heavy chain variable region, wherein the light chain variable region has three CDRs of a light chain variable region set forth as SEQ ID NO:
- 93, SEQ ID NO:
- 99, or SEQ ID NO:
- 105;
- and the heavy chain variable region has three CDRs of a heavy chain variable region set forth as SEQ ID NO:
- 95, SEQ ID NO:
- 97, SEQ ID NO:
- 101, SEQ ID NO:
- 103 or SEQ ID NO:
- 107.
An antibody drug conjugate (ADC) of the formula Ab-[L-D]n or a pharmaceutically acceptable salt thereof wherein:
- Ab comprises an anti-MFI2 antibody;
- L comprises an optional linker;
- D comprises a drug;
- and
- n is an integer from 1 to 20.
A method of detecting, diagnosing, or monitoring cancer in a subject, the method comprising the steps of contacting an MFI2 determinant associated with a tumor cell with a detection agent and detecting the detection agent associated the tumor cells.
Dependencies are inferred from the claim text.