Therapeutic agent for autoimmune diseases comprising pd-1 agonist
AssigneeOno Pharmaceutical Co., Ltd.
InventorsShiro SHIBAYAMA, Masamichi IMAI
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Abstract
Provided is a prophylactic, symptom progress-suppressive, and/or therapeutic agent for an autoimmune disease. The agent lowers the risk of infections and reduces the burden of administration to patients. The prophylactic, symptom progress-suppressive, and/or therapeutic agent includes a PD-1 agonist as an active ingredient and is administered (a) 1 to 10 times within one month from the first administration, (b) in a total PD-1 agonist dose of 20 to 1250 μg/kg, and (c) without requiring administration for at least 3 months after the last administration.
Claims20
A symptom progress-suppressive and/or therapeutic method for treating or preventing onset of an autoimmune disease, comprising administering an agent comprising a PD-1 agonist as an active ingredient to a subject, wherein
- (a) the agent is administered 1 to 10 times within one month from a first administration,
- (b) a total dose of the PD-1 agonist, in (a), is 20 μg/kg or more, and
- (c) the administration of the agent is not necessary for at least 3 months after a last administration of (a).
A method for sustaining a symptom progress-suppressive and/or therapeutic effect in an autoimmune disease for at least 3 months after a last administration of a PD-1 agonist, comprising administering the PD-1 agonist to a patient having the autoimmune disease 1 to 10 times within one month from a first administration at a total dose of 20 μg/kg or more.
A prophylactic, symptom progress-suppressive, and/or therapeutic method for an autoimmune disease, comprising administering a agent comprising a PD-1 agonist as an active ingredient to a subject, wherein
- (a) the agent is administered 1 to 10 times within one month from a first administration,
- (b) a total dose of the PD-1 agonist in (a) is 20 μg/kg or more, and
- (c) the agent is not administered for at least 3 months after a last administration of (a).
Dependencies are inferred from the claim text.