Cs1-specific chimeric antigen receptor engineered immune effector cells
AssigneeOhio State Innovation Foundation
InventorsJianhua Yu, Craig Hofmeister, Jianhong Chu
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Abstract
Disclosed herein are chimeric antigen receptors (CAR) that can specifically recognize tumor-associated antigens (TAA) on multiple myeloma (MM) cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with MM that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
Claims15
-12. (canceled)
A method of providing an anti-tumor immunity in a subject with multiple myeloma (MM), the method comprising administering to the subject an effective amount of an immune effector cell genetically modified to express a chimeric antigen receptor (CAR) wherein the CAR comprises a CS1 antigen binding domain, a costimulatory signaling region, and a CD3 zeta signaling domain, thereby providing an anti-tumor immunity in the subject.
Dependencies are inferred from the claim text.