Anti-alpha-synuclein antibodies and methods of use
AssigneeGenentech, Inc.
InventorsGai Ayalon, Till Mauer
Life of this patent
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Abstract
The present invention relates to anti-alpha-synuclein (anti-α-synuclein) antibodies and methods of using the same.
Claims15
An isolated monoclonal antibody that competes with an anti-α-synuclein antibody for binding to human α-synuclein, wherein the anti-α-synuclein antibody comprises three heavy chain hypervariable regions (HVR-H1, HVR-H2, and HVR-H3) and three light chain hypervariable regions (HVR-L1, HVR-L2, and HVR-L3), wherein:
- (a) HVR-H1 comprises the amino acid sequence of SEQ ID NO:9;
- (b) HVR-H2 comprises the amino acid sequence of SEQ ID NO:10;
- (c) HVR-H3 comprises the amino acid sequence of SEQ ID NO:11;
- (d) HVR-L1 comprises the amino acid sequence of SEQ ID NO:6;
- (e) HVR-L2 comprises the amino acid sequence of SEQ ID NO:7;
- and
- (f) HVR-L3 comprises the amino acid sequence of SEQ ID NO:8.
An isolated monoclonal antibody that binds to the same epitope in human α-synuclein as an anti-α-synuclein antibody comprising three heavy chain hypervariable regions (HVR-H1, HVR-H2, and HVR-H3) and three light chain hypervariable regions (HVR-L1, HVR-L2, and HVR-L3), wherein:
- (a) HVR-H1 comprises the amino acid sequence of SEQ ID NO:9;
- (b) HVR-H2 comprises the amino acid sequence of SEQ ID NO:10;
- (c) HVR-H3 comprises the amino acid sequence of SEQ ID NO:11;
- (d) HVR-L1 comprises the amino acid sequence of SEQ ID NO:6;
- (e) HVR-L2 comprises the amino acid sequence of SEQ ID NO:7;
- and
- (f) HVR-L3 comprises the amino acid sequence of SEQ ID NO:8.
An isolated monoclonal antibody that competes with an anti-α-synuclein antibody for binding to human α-synuclein, wherein the anti-α-synuclein antibody comprises three heavy chain hypervariable regions (HVR-H1, HVR-H2, and HVR-H3) and three light chain hypervariable regions (HVR-L1, HVR-L2, and HVR-L3), wherein:
- (a) HVR-H1 comprises the amino acid sequence of SEQ ID NO:15;
- (b) HVR-H2 comprises the amino acid sequence of SEQ ID NO:16;
- (c) HVR-H3 comprises the amino acid sequence of SEQ ID NO:17;
- (d) HVR-L1 comprises the amino acid sequence of SEQ ID NO:12;
- (e) HVR-L2 comprises the amino acid sequence of SEQ ID NO:13;
- and
- (f) HVR-L3 comprises the amino acid sequence of SEQ ID NO:14.
An isolated monoclonal antibody that binds to the same epitope in human α-synuclein as an anti-α-synuclein antibody comprising three heavy chain hypervariable regions (HVR-H1, HVR-H2, and HVR-H3) and three light chain hypervariable regions (HVR-L1, HVR-L2, and HVR-L3), wherein:
- (a) HVR-H1 comprises the amino acid sequence of SEQ ID NO:15;
- (b) HVR-H2 comprises the amino acid sequence of SEQ ID NO:16;
- (c) HVR-H3 comprises the amino acid sequence of SEQ ID NO:17;
- (d) HVR-L1 comprises the amino acid sequence of SEQ ID NO:12;
- (e) HVR-L2 comprises the amino acid sequence of SEQ ID NO:13;
- and
- (f) HVR-L3 comprises the amino acid sequence of SEQ ID NO:14.
An isolated antibody that binds to human α-synuclein, wherein the antibody binds a region or epitope of human α-synuclein comprising amino acid residues 5-43 of human α-synuclein.
An isolated antibody that binds to human α-synuclein, wherein the antibody binds a region or epitope of human α-synuclein comprising amino acid residues 5-78 of human α-synuclein, wherein the amino acid residues are numbered according to the human α-synuclein amino acid sequence of SEQ ID NO:1.
An isolated antibody that binds to human α-synuclein, wherein the antibody binds a region or epitope of human α-synuclein comprising amino acid residues 37-51 of human α-synuclein, wherein the amino acid residues are numbered according to the human α-synuclein amino acid sequence of SEQ ID NO:1.
An isolated antibody that binds to human α-synuclein, wherein the antibody binds a region or epitope of human α-synuclein comprising amino acid residues 104-118 of human α-synuclein, wherein the amino acid residues are numbered according to the human α-synuclein amino acid sequence of SEQ ID NO:1.
Dependencies are inferred from the claim text.