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US 2017/0320937 A1Published application
Anti-influenza b virus hemagglutinin antibodies and methods of use
AssigneeGenentech, Inc.
InventorsLee Swem, Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Gerald R. Nakamura, Hyunjoo Park
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Abstract
The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.
Claims9
An isolated anti-hemagglutinin monoclonal antibody that specifically binds influenza B virus hemagglutinin, wherein the antibody comprises three heavy chain hypervariable regions (HVR-H1, HVR-H2, and HVR-H3) and three light chain hypervariable regions (HVR-L1, HVR-L2, and HVR-L3), wherein:
- (a) HVR-H1 comprises the amino acid sequence of SEQ ID NO:63;
- (b) HVR-H2 comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:67, 68, 69, 70, 71, 72, 73, and 74;
- (c) HVR-H3 comprises the amino acid sequence of SEQ ID NO:77;
- (d) HVR-L1 comprises the amino acid sequence of SEQ ID NO:56;
- (e) HVR-L2 comprises the amino acid sequence of SEQ ID NO:58;
- and
- (f) HVR-L3 comprises the amino acid sequence of SEQ ID NO:60.
4 more elements
Dependencies are inferred from the claim text.