Cd44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases

A compound comprising:

• a cyclic peptide comprising at least
• (a) an amino acid X1 being selected from the group consisting of the amino acids A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W and Y, further
• (b) an amino acid sequence R-W-H, and further
• (c) an amino acid X11 being selected from the group consisting of the amino acids A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W and Y, or a peptidomimetic thereof, or
• a cyclic peptide comprising at least the amino acid sequence X1-X2-X3-X4-X5-X6-X7-R-W-H-X11-X12-X13-X14, wherein the amino acid X1 is selected from the group consisting of the amino acids A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W and Y, wherein the amino acids X2, X3, X4, X5, X6, X7, X11, X12, X13 and X14 are independently selected from the group consisting of the amino acids A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W and Y, and wherein X2, X3, X4, X5, X6, X7, X12, X13 and X14 are optionally present in the amino acid sequence, or a peptidomimetic thereof,
• the compound comprising a chemical bond between two adjacent amino acids of the cyclic peptide which is not a chemical bond between the N-terminus of a first amino acid and the C-terminus of a second amino acid of the two adjacent amino acids.