Modified Kappa Light Chain-Binding Polypeptides
AssigneeGE Healthcare BioProcess R&D AB
InventorsGustav Rodrigo, Mats Ander, Tomas Bjorkman
Life of this patent
Estimating the term…
Abstract
The invention discloses kappa light chain-binding polypeptide comprising a mutated binding domain of Peptostreptococcus protein L, wherein at least one asparagine residue of a parental domain defined by, or having at least 95% or 98% sequence homology with, SEQ ID NO: 2-6 or 2 has been mutated to another amino acid residue which is not asparagine, proline or cysteine.
Claims20
A kappa light chain-binding polypeptide comprising at least one mutated binding domain of Peptostreptococcus Protein L, in which domain at least one asparagine residue of a parental domain defined by, or having at least 95% or 98% sequence homology with, SEQ ID NOS:
- 2-6 or 12 has been mutated to another amino acid residue which is not asparagine, proline or cysteine.
Dependencies are inferred from the claim text.