Inhibitors for inhibiting tumor metastasis

A compound in accordance with Formula I:

• wherein:
• R1:
• is H, acyl, peptidyl, sulfonyl, alkyl, aryl or heteroaryl, wherein the acyl, peptidyl, sulfonyl, alkyl, aryl or heteroaryl substituents are optionally substituted with halogen, acyl, carboxyl, amino, carbamoyl, OH, O-alkyl, SH, S-alkyl, alkyl, aryl or heteroaryl;
• R2:
• is H, alkyl, cycloalkyl, alkenyl, alkynyl or halogen, O-alkyl, S-alkyl, aryl or heteroaryl, wherein the alkyl, cycloalkyl, alkenyl, alkynyl, O-alkyl, S-alkyl, aryl or heteroaryl substituents are optionally substituted with halogen, acyl, carboxyl, amino, carbamoyl, OH, O-alkyl, SH, S-alkyl, alkyl, aryl or heteroaryl;
• R3:
• is a C-containing substituent selected from the group consisting of alkyl;
• acyl;
• a carboxylic acid derivative in accordance with C(═O)X, wherein X═OH, O-alkyl or O-aryl;
• NRR′ NROR′, wherein R, R′═H or alkyl;
• and heteroaryl;
• and
• Z:
• is CH2 or CH2CH2.