Heterocyclic derivatives and use thereof

A compound selected from the group consisting of a heterocyclic derivative represented by formula (I), and a pharmaceutically acceptable salt and a stereoisomer thereof:

• wherein
• one of X1, X2, X3 and X4 is —C(-Rx)=, and the others are each independently —C(-Rx′)= or —N═;
• one of Y and Z is —S— or —NH—, and the other is —CH═ or —N═;
• Rx is
• Xs is ═O or ═NH;
• Ls is —C(—Rs′)(-Rs″)- or —N(-Rs′)-;
• Rs is C1-6alkyl, haloC1-6alkyl, C1-6alkoxy-C1-6alkyl, C1-6alkylcarbonyl-C1-6alkyl, C2-7alkenyl, amino, aminoC1-6alkyl or 5- to 10-membered heterocyclyl, or Rs is linked to Rs′ to form a chain;
• Rs′ and Rs″ are each independently hydrogen, halogen, C1-6alkyl, carbamoyl-C1-6alkyl, C1-6alkylamino-C1-6alkyl or diC1-6alkylamino-C1-6alkyl, or Rs′ and Rs″ are linked together to form a chain, or Rs′ is linked to Rs to form a chain;
• Rx′ is each independently hydrogen, halogen, nitro, amino, C1-6alkoxy, haloC1-6alkoxy, or C1-6alkylsulfonyl;
• A and B are each independently a monocyclic- or bicyclic-saturated or unsaturated C3-10carbocycle or 5- to 12-membered heterocycle;
• Rc is ═O, ═NH, ═N(—C1-6alkyl), or ═N(—OH);
• RN is hydrogen or C1-6alkyl, or RN is linked to RA to form a chain;
• LB is —[C(—RL)(—RL′)]m—, —[C(—RL)(—RL′)]n—O—, —O—, —NH—, —N(C1-6alkyl)-, —S(═O)2—, —C(═O)—, or —C(═CH2)—, wherein m is an integer of 0 to 3, n is an integer of 1 to 3, RL and RL′ are each independently hydrogen, hydroxy, halogen or C1-6alkyl, or RL and RL′ are linked together to form a chain;
• RA is hydrogen, halogen, cyano, C1-6alkyl, haloC1-6alkyl, cyanoC1-6alkyl, C1-6alkylcarbonyl, C1-6alkoxy, haloC1-6alkoxy, cyanoC1-6alkoxy, C1-6alkylamino, diC1-6alkylamino, C1-6alkylthio, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, C2-8alkynyl, C1-6alkoxycarbonylamino-C1-6alkoxy, aminoC1-6alkoxy or 3- to 6-membered heterocyclyl, or RA is linked to RN to form a chain;
• RB is hydrogen, halogen, hydroxy, cyano, nitro, amino, oxo, aminosulfonyl, sulfonylamido, C1-6alkylamino, C1-6alkyl, haloC1-6alkyl, cyanoC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, cyanoC1-6alkoxy, C3-8cycicoalkyloxy, C2-8alkenyl, C2-8alkenyloxy, C2-8alkynyl, C2-8alkynyloxy, C1-6alkylamino-C1-6alkoxy, diC1-6alkylamino-C1-6alkoxy, C1-6alkoxycarbonyl, carbamoyl, carbamoyl-C1-6alkoxy, C1-6alkylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, 5- to 10-membered heterocyclyl, 5- to 10-membered heterocyclyl-C1-6alkyl, 5- to 10-membered heterocyclyl-C1-6alkoxy, or 5- to 10-membered heterocyclyl-oxy;
• p is an integer of 0 to 4, and, when p is 2 or higher, RA moieties are the same as or different from each other;
• q is an integer of 0 to 4, and, when q is 2 or higher, RB moieties are the same as or different from each other;
• and
• each of said chains is independently a saturated or unsaturated C2-10 hydrocarbon chain not containing or containing at least one heterogroup selected from the group consisting of —O—, —NH—, —N═, —S—, —S(═O)— and —S(═O)2— in the chain, and unsubstituted or substituted with at least one selected from the group consisting of halogen, C1-6alkyl and C1-6alkoxy;
• and
• each of said heterocycle and heterocyclyl moieties independently contains at least one heterogroup selected from the group consisting of —O—, —NH—, —N═, —S—, —S(═O)— and —S(═O)2—.