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US 2017/0320879 A1Published application
A process for the preparation of ibrutinib
AssigneeSun Pharmaceutical Industries Limited
InventorsKapil SHARMA, Bhavin Prabhudas THANKI, Mahavir Singh KHANNA, Mohan PRASAD
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Abstract
The present invention provides processes for the preparation of ibrutinib, intermediate compounds of Formula VI and Formula VIII, and salts thereof. The processes of the present invention are commercially viable, cost-effective, environmentally friendly, and make use of inexpensive, non-hazardous, safe chemicals that are easy to handle.
Claims21
1-40. (canceled)
A process for the preparation of a compound of Formula VIII,
- wherein X is halogen,
- comprising reacting a compound of Formula VI or its salts,
- wherein X is halogen;
- with a compound of Formula VII,
- wherein R is hydroxy, halogen, tosyl, or mesyl,
- to obtain the compound of Formula VIII.
3 more elements
A process for the preparation of a compound of Formula VI or its salts,
- wherein X is halogen,
- the process comprising deprotecting a compound of Formula V,
- wherein X is halogen, and
- Pr1 is an N-protecting group selected from the group consisting of tert-butyloxycarbonyl, benzyloxycarbonyl, 2-(trimethylsilyl)ethoxycarbonyl, benzyl, benzoyl, carbamate, tosyl, and p-methoxybenzyl carbonyl,
- with a deprotecting agent to obtain the compound of Formula VI or its salts.
2 more elements
A compound of Formula VIa or its salts
A compound of Formula VIII,
- wherein X is halogen.
Dependencies are inferred from the claim text.