Substituted pyridinones as bromodomain inhibitors

A compound of Formula I:

• or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof,
• wherein:
• A is selected from aryl (C5-C10), heteroaryl (C2-C5), and heteroaryl (C5-C10) optionally substituted with 1 to 3 groups independently selected from halogen, alkyl (C1-C6), alkoxy (C1-C6), —CF3, —CN, —C(O)NHR1, —C(O)R1, —SO2R1, —S(O)R1, and —NR1R2;
• L is selected from —CH2—, —CH2CH2— and —CH(CH3)— optionally substituted with halogen;
• or
• L may be absent in which case A is connected to X via a covalent bond;
• X is selected from —O— and —NH—;
• R1 and R2 are independently selected from hydrogen and alkyl (C1-C6);
• and
• R3 and R4 are independently selected from alkyl (C1 C6) optionally substituted with halogen and hydroxyl.