Process for the preparation of brexpiprazole and intermediates thereof
AssigneeCadila Healthcare Limited
InventorsSanjay Jagdish DESAI, Jayprakash Ajitsingh PARIHAR, Alpesh Pravinchandra SHAH
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Abstract
The present invention relates to Brexpiprazole having a purity of about 99.5% or more by area percentage of HPLC, having total impurities not more than 0.5% relative to brexpiprazole as measured by area percentage of HPLC, and having less than 0.1% 1-(benzo[b]thiophen-4-yl)piperazine or a salt thereof relative to brexpiprazole by area percentage of HPLC. The present invention also provides a composition comprising brexpiprazole having 1-(benzo[b]thiophen-4-yl)-piperazine or a salt thereof in an amount less than about 0.1% relative to brexpiprazole by area percentage of HPLC and process for the preparation of brexpiprazole.
Claims20
Brexpiprazole having a purity of about 99.5% or more by area percentage of HPLC.
A composition comprising brexpiprazole having 1-(benzo[b]thiophen-4-yl)-piperazine or a salt thereof in an amount less than about 0.1% relative to brexpiprazole by area percentage of HPLC.
A compound of of Formula (III),
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Dependencies are inferred from the claim text.