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US 2017/0320836 A1Published application
Processes for the preparation of uracil derivatives
AssigneeNeurocrine Biosciences, Inc.
InventorsDonald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
Life of this patent
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Abstract
The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
Claims4
1-5. (canceled)
A process for preparing a compound of structure:
- wherein:
- R1a, R1b and R1c are the same or different and independently hydrogen, halogen, C1-4alkyl, hydroxy or alkoxy;
- R2a and R2b are the same or different and independently hydrogen, halogen, trifluoromethyl, cyano or —SO2CH3;
- R3 is hydrogen or methyl;
- and
- comprising:
- reacting a compound of structure (VII):
- wherein R2a, R2b and R3 are as defined above;
- with a compound of structure (VIII):
- wherein R is H or C1-4alkyl, R′ is H or C1-4alkyl or R and R′ taken together form C1-6alkanediyl;
- and
- R1a, R1b, and R1c are as defined above.
9 more elements
8-11. (canceled)
Dependencies are inferred from the claim text.