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US 2017/0320830 A1Published application
Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission
AssigneeSiemens Healthcare Diagnostics Inc.
InventorsAnand Natrajan, David Sharpe, Qingping Jiang, David Wen
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Abstract
Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.
Claims20
A hydrophilic, high quantum yield acridinium ester having the following structure:
- wherein,
- R1 is a methyl or sulfopropyl group;
- G is a branched group independently selected at each occurrence from:
- where R2, R3, R4, R5, R6 and R7 are independently at each occurrence a methyl group or a group —(CH2CH2O)nCH3, where n is an integer from 1 to 5;
- and
- R12 is an electrophilic or nucleophilic group for conjugating the acridinium compound to an analyte, an analyte analog, or a binding molecule for an analyte.
3 more elements
The acridinium ester according to any of claims 14-18, wherein R12 is —OH.
Dependencies are inferred from the claim text.