US 2017/0320825 A1 · NOVEL PENTADIENOYL PIPERIDINE DERIVATIVE AND USE THEREOF

Abstract

The present invention relates to a novel pentadienoyl piperidine derivative, a pharmaceutical composition containing the same for prevention or treatment of metabolic diseases, and a functional food composition using the same for improvement or relief of metabolic diseases. The pentadienoyl piperidine derivative of the present invention inhibits the differentiation of preadipocytes, reduces body weight, visceral fat, blood lipid levels, and blood glucose levels, improves a blood liver function index, and suppresses metabolic inflammation responses. Thus, ultimately, the derivative can be usefully used as a medicine or a functional food composition, which exhibits the preventive or therapeutic activity for metabolic diseases selected from the group consisting of obesity, diabetes, dyslipidemia, fatty liver and insulin resistance syndrome.

Claims11

Dependent claims

A pentadienoyl piperidine derivative represented by Formula 1 below or a pharmaceutically acceptable salt thereof:

wherein R1 is a C1-C3 alkyl group.

Dependencies are inferred from the claim text.

Facts

Application

15/513,072Filed 22 Sep 2015

Priority

KR 10-2014-012695923 Sep 2014

Published

9 Nov 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 211/32
With hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon…
A61K 31/4453
Non condensed piperidines, e.g. piperocaine: only substituted in position 1, e.g. propipocaine, diperodon
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics

Novel pentadienoyl piperidine derivative and use thereof

Life of this patent

Novel pentadienoyl piperidine derivative and use thereof

Life of this patent

Abstract

Claims11