Back to results
US 2017/0320824 A1Published application
MAP4K4 (HGK) Inhibitors
AssigneeSRI International
InventorsLing Jong, Chih-Tsung Chang, Jaehyeon Park
Life of this patent
Estimating the term…
Abstract
The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.
Claims20
The compound of claim 1 of formula II:
- wherein:
- R1-R5 and R10 are independently H, halo, OH, or C1-C9 alkyl, alkyl amine or alkyl ether, each of which is substituted or unsubstituted and comprises 0-3 heteroatoms selected from N, O, S and P;
- R6-R7 are independently N or CR10;
- and
- R8-R9 are independently H or Me, or
- a pharmaceutically acceptable salt, hydride or stereoisomer thereof.
3 more elements
Dependencies are inferred from the claim text.