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AssigneeTaminco BVBA
InventorsKristof Moonen, Kim Dumoleijn, Laura Prati, Alberto Villa
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Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Pt, Rh, Ir, and Ru, and in absence of any catalytic amount of any second metal from the list consisting of Ag, Ni, Co, Sn, Bi, Cu, Au, and combinations thereof. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of active agrochemical compounds and microbicides of the methoximinophenylglyoxylic ester series.
A process for performing a reductive amination of a first functional group on an organic feed substrate, which feed substrate comprises at least one further functional group comprising a halogen atom, wherein the halogen atom comprises chlorine, bromine, iodine, or combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one first metal comprising palladium, platinum, rhodium, iridium, and ruthenium, and in absence of a catalytic amount of any second metal selected from the list consisting of silver, nickel, cobalt, tin, bismuth, copper, gold, and combinations thereof, whereby the heterogeneous catalyst has been heat-treated prior to the reductive amination at a temperature in the range of 100° C. to 600° C. for a period of at least one hour.
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Dependencies are inferred from the claim text.